Cursol, Bioavailable Curcumin for Inflammatory Pathologies

A natural and safe anti-inflammatory alternative

Cursol^TM contains a highly soluble curcumin extract (Curcuma longa L.) in a patented formulation involving food grade emulsifiers that increase significantly its assimilation.

Its active principal acts on the symptoms of all inflammatory pathologies, caused by numerous diseases (for example ostheoarthritis, gastrointestinal disorders) to relieve:

joint pain and cartilage degradation,

abdominal pain (troubles associated to intestinal disorders)

Due to the excellent safety profile of the active ingredient, Cursol^TM can safely be taken on a chronic basis.

Cursol Formulation

Cursol is a powder formulation standardized at 21 mg/gr curcumin in a highly soluble and bioavailable form.

The highly free flowing powder form of CURSOL^TM allows any possible mixture with other active ingredients in powder form for targeting a selected pathology.

This bio-optimized formulation of turmeric is based on a patented formula in association with a patented drying process allowing the preservation of the active principle.

With no side effects, CURSOL^TMcan be used for long periods without digestive complications.

The minimum recommended daily intake is 500 mg of CURSOL^TM per day.

Cursol Clinical Data

Cursol^TM is delivered with a complete package of information, including bioXtract proprietary:

Pre-clinical trials evaluating:
- Evaluation of Cursol^TM Acute Oral Toxicity,
- In Vitro Evaluation for Cursol^TM efficacy for its activity on chondrocytes and cartilage inflammation.

The trials confirmed the anti-inflammatory action of Cursol^TM as well as its chondroprotective activity, making it the best natural ingredient for pain relief for osteoarthritis.

The effects of Cursol^TM formulated Curcumin on PGE₂ and NO production have been compared with those of Indomethacin and Celecoxib. In contrary to NSAID's, Cursol^TM also inhibited NO production. This suggests that Curcumin is not only a PGE₂ inhibitor, but also an inhibitor of factors contributing to cartilage degradation and inflammatory cell recruitment.

Clinical trials:

As the solubility of the curcumin is the main issue for its bioavailability, and as it is very difficult to compare between them the pharmacokinetics studies on humans of marketed products due to their huge differences in protocols and conditions, it was decided to compare the solubility of Cursol^TM to the major Curcumin formulations available on the market in the same conditions.

This study reveals Cursol^TM has the most soluble formulation.

Phase I clinical trial, assessing the bioavailability of Cursol^TM. A compared bioavailability versus Meriva^® (lecitin formulation from the company INDENA) revealed Cursol^TM's superiority in terms of soluble and assimilated curcumin.

Significantly decreases all inflammatory processes,
Significantly imroves Quality of Life of osteoarthritis patients,
Improvement noted wihtin a few days,
Minimum recomended dosage of 250mg per day up to 1gr for acute pain.

Cursol^TM is a patented active ingredient offering highly soluble curcumin with powerful anti-inflammatory action.

Cursol^TM is particularly designed for all pathologies involving inflammatory processes. Its highly free flowing powder form allows any possible mixture with other active ingredients for targeting a selected pathology.

There is a real need for natural and side-effects free anti-inflammatory ingredients with high security of use and level of activity. Numerous anti-inflammatory drugs present a lot of side-effects and cannot be administrated for a chronic use.

Cursol^TM is a natural alternative to the classical NSAID's drugs.

Taking Cursol^TM on a chronic basis will achieve a steady state of curcumin in the plasma. This will prevent from inflammatory processes.