Arantal

Joint Care

ARANTAL is a natural product designed for the relief of pain in rheumatology

Its patented formula, based on a bio-optimized extract of turmeric, considerably improves joint comfort by acting on 2 levels:

-  on the complaints, by quickly relieving joint discomfort.

-  on wear and tear, by slowing down the damage to the cartilage.

Arantal is available under several dosage forms : gelatin sogtgels or HPMC hardshell

 

Formulation

1) ARANTAL Clear Gelatin softgel capsule (size 10 oval) : gelatin soft capsule of 920 mg containing a quantity of turmeric extract corresponding to 42.0 mg of curcumin in highly bioactive form.

2) ARANTAL HPMC Regular hardshell capsule (size 00) : 100% hypromellose hard capsules of 948 mg containing a quantity of turmeric extract corresponding to min. 44.0 mg of curcumin in highly bioactive form.

3) ARANTAL HPMC Vegan hardshell capsule (size 00) : 100% hypromellose hard capsules of 948 mg containing a quantity of turmeric extract corresponding to min. 44.0 mg of curcumin in highly bioactive form and 2.50 µg of vitamin D3 (cholecalciferol) from vegetal origin.

Arantal bulk formulation (bulk oily gel formulation for encapsulation) is also possible upon request, please feel free to contact us for any further information.

Clinical data

BioXtract in vitro studies on curcumin show that curcumin:

  • inhibits pro-inflammatory mediators (PGE2, IL-6, IL-8) and acts on the pain of osteoarthritis,
  • inhibits COX-2 but not COX-1 gene expression, and gives pain relief without unwanted gastro-intestinal side effects,
  • inhibits the synthesis of NO and prevents cartilage breakdown in the joint. 

 

ARANTAL is delivered with a complete package of information, including bioXtract proprietary:

  • Pre-clinical acute oral toxicity trial in rats showing no particular effect and classifying the product in the danger 5 category DL50 superior 5,000 mg/kg,
  • Phase I clinical trial demonstrating bioavailability of ARANTAL's active principals. (Complete report available on request),
  • Phase II randomised, double-blind, multicenter clinical trial to evaluate the analgesic efficacy of ARANTAL in patients suffering from gonarthrosis, on a short term period (2 weeks),
  • Observational cohort study of ARANTAL on 1,077 patients suffering from osteoarthritis,
  • Clinical evaluation of the efficacy of ARANTAL during 6 months on 820 patients suffering from various joint painful osteoarthritis, 
  • Non-comparative exploratory study evaluating the clinical efficacy of ARANTAL on pain, side effects and effects on some biomarkers of osteoarthritis,
  • Observational Study of Gout Attack on 54 patients,
  • Safety Evaluation in aged patients with osteoarthritis and comorbidity.

See slides hereunder for more information.