NEWS

19-03-18
Vitafoods Europe 2018

 

15-17 May 2018

Geneva

 

Meet us at stand K72

Regulid Plus, a natural weight stabilizer

Stabilize Weight and Fight Yo-Yo Effect

Advantages of Regulid Plus®

  • Stabilize weight and fight yo-yo effect

  • Reduce adipocyte differentiation & increase lipolysis

  • Anti-inflammatory action

  • Natural extract of omega-3 and organic garlic (vinyldithiins and allylsulfides)



The yo-yo dieting

Most of us are familiar with the concept of yo-yo dieting: losing weight during a crash or fad diet, and regaining it as soon as the diet is over. This cyclical pattern of weight loss and gain ultimately results in a net weight gain, with some potentially damaging effects on the body - not to mention the psychological effects of being trapped in this yo-yo pattern.

 

Taking natural treatment Regulid may help stabilize weight.

 

Research has shown that taking Regulid Plus® during a sensible weight loss diet, and continuing to take it for 3-6 months afterwards may help maintain the post-diet weight by inhibiting the process by which fat cells store up on fat. The specific garlic active principals in Regulid Plus® have been shown to affect the metabolism of adipocytes (fat cells) and to also have a beneficial effect on cholesterol levels, in particular Triglycerides and HDL.

 

 

 

Regulid Plus Formulation

Regulid Plus® is a unique and innovative formulation based on the mediterranean diet associating garlic, olive oil and Omega-3 from fish oil in a gelatine capsule of 456 mg.

 

 

Each capsule contains:

 

  • 125 mg of omega-3 fatty acids (EPA + DHA) corresponding to 50% of GDA (Guideline Daily Amounts).
  • a standardized dose of total active principles from garlic (vinyldithiins and sulfides) of 0.1065 mg (-10%/+20%)

 

 

Potential nutrition and health claims:

 

  • High omega-3 Fatty Acids content

  • High EPA/DHA content

  • EPA and DHA contribute to the normal function of the heart (the beneficial effect is obtained with a daily intake of 250 mg of EPA and DHA, corresponding to 2 capsules of Regulid Plus).

 

 Suggested use of Regulid Plus® is 2 capsules a day before meal with a large glass of water.

Regulid Plus to fight yo-yo dieting syndrome

 

REGULID Plus® active principals affect specific stages of the adipocyte life cycle [1].

1,2-vinyldithiin in Regulid Plus® inhibits preadipocyte differentiation and reduces lipid accumulation in maturing preadipocytes. It also triggers lipolysis in mature adipocytes, and in combination with DADS, it reinforces even more the induction of lipolysis.


Since a number of complexed interconnected cell signaling pathways are involved in regulating the adipocyte cycle, treating adipocytes with multiple natural molecules results in enhanced effects. By targeting preadipocyte differentiation, lipid filling in maturing preadipocytes and also by increasing
lipolysis, Regulid Plus® offers a complete solution for adipocyte management during dieting and also during the stabilization period following a diet.


By reducing the appearance of new adipocytes, reducing their capability for storing fat and increasing lipolysis, Regulid Plus® helps stabilize the amount of fat in the body, and reduce the unavoidable refilling of adipocytes after a diet.

 

 

 

Regulid Plus to help manage metabolic syndrome

Regulid Plus® active principals have also demonstrated their positive effects on regulation of Triglycerides and Good Cholesterol (HDL) levels, in a clinical trial conducted by Bordia in 1981 [2].

This double-blind, randomized, placebo-controlled study demonstrated the efficacy of a garlic preparation (with the same composition as REGULID) on the different lipid blood fractions (in particular on TG and HDL).

 

 

Regulid Plus Master File

 

Regulid Plus® is delivered with a completel scientific dossier, detailing:

 

bioXtract pre-clinical trials evaluating:

  • the efficacy of Regulid Plus® active principal on in vitro adipocyte metabolism,
  • lack of oral toxicity (acute oral toxicity tests on rats).


Bibliographical clinical data

  • Bibiliographical Phase II clinical results obtained with a Regulid Plus® equivalent composition.

 

Regulid Plus® is a food supplement registered in Belgium and France.

 


[1] Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D. 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J. Nutr. 2009; 139: 2055-2060.

 

[2] Bordia A. Effect of garlic on blood lipids in patients with coronary heart disease. Am. J. Clin. Nutr. 1981, 34; 2100-2103.