Curcumin as Immunomodulator
Curcumin is highly lipophilic and almost insoluble in water at pH values below 7. The solubility is a critical parameter when it comes to bioavailability of curcumin as a potential drug. The low aqueous solubility is probably the most important factor contributing to the low absorption of curcumin from the gastrointestinal tract and the low bioavailablity previously reported .
bioXtract has developed an innovative proprietary formulation to enhance the solubility of this active principal, using β-cyclodextrin complexation, as well as other highly solubilising additives.
Bioavailability of bioXtract innovative curcumin formulation has been evaluated on humans, showing higher plasma levels of active principal compared to standard curcumin formulations.
 Hegge AB, Schüller RB, Kristensen S, Tonnesen HH. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoids. XXXIII. Pharmazie. 2008; 63: 585-592.